14 December 2022 An international research team has identified ‘born to be bad' colorectal tumours in people with early stage cancer, which could help medical experts pinpoint and better treat aggressive tumours.The team from Monash University, CRUK Beatson Institute in Glasgow and Queen's University in Belfast found a feature of early-stage colorectal tumours in mice and humans, known as TGFβ signalling, that is active in tumour cells and is profoundly tumour-promoting.In this group of patients, epithelial TGFβ signalling predicted how aggressive, treatment-resistant and lethal the cancer was/is.

https://www.monash.edu/discovery-institute/news-and-events/news/2022-articles/researchers-identify-born-to-be-bad-colorectal-cancer-tumours

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